Structure of an Hsp90-Cdc37-Cdk4 Complex
نویسندگان
چکیده
منابع مشابه
Structure of an Hsp90-Cdc37-Cdk4 complex.
Activation of many protein kinases depends on their interaction with the Hsp90 molecular chaperone system. Recruitment of protein kinase clients to the Hsp90 chaperone system is mediated by the cochaperone adaptor protein Cdc37, which acts as a scaffold, simultaneously binding protein kinases and Hsp90. We have now expressed and purified an Hsp90-Cdc37-Cdk4 complex, defined its stoichiometry, a...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2006
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2006.07.016